The nefarious Dr. Fu Manchu searches for the keys to the tomb of Genghis Khan, in order to fulfill a prophecy that will enable him to conquer the world. His nemesi, Dr. Nayland Smith and his associates fight to keep the evil doctor from getting his hands on the keys. In 1943 the serial was edited together into a feature movie also called Drums of Fu Manchu.

• Henry Brandon
• William Royle
• Robert Kellard
• Luana Walters
• Olaf Hytten
• Tom Chatterton
• Gloria Franklin
• John Merton